LOCUS       CM079528               10132 bp    DNA              UNK 01-JAN-1980
DEFINITION  Rubus argutus cultivar Hillquist isolate PI 553951 chromosome 1,
            whole genome shotgun sequence.
ACCESSION   CM079528
VERSION     CM079528.1
KEYWORDS    .
SOURCE      .
  ORGANISM  .
            .
FEATURES             Location/Qualifiers
     cluster         1..10132
                     /note="Cluster number: 3"
                     /note="Detection rule(s) for this cluster type:
                     plants/lignan: (minimum(3,[NAD_binding_4, FAE1_CUT1_RppA,
                     HAD_RAM2_N,
                     Orn_DAP_Arg_deC,Pyridoxal_deC,BBE,FA_hydroxylase,CER1-like_
                     C,ECH_2,Oxidored_FMN,3Beta_HSD,Glyco_hydro_1,ADH_N,ADH_N_2,
                     Abhydrolase_3,Aldo_ket_red,cMT,nMT,oMT,adh_short,Chal_sti_s
                     ynt_C,Chal_sti_synt_N,COesterase,UDPGT,Glyco_transf_28,Glyc
                     os_transf_1,Glycos_transf_2,Lycopene_cycl,NAD_binding_1,p45
                     0,SQHop_cyclase_C,SQHop_cyclase_N,Prenyltrans,Terpene_synth
                     _C,Terpene_synth,Transferase,Aminotran_1_2,AMP-binding,DIOX
                     _N,Dirigent,Bet_v_1,Cu_amine_oxid,Str_synth,Trp_syntA,His_b
                     iosynth,adh_short_C2,Peptidase_S10,Prenyltransf,Epimerase,2
                     OG-FeII_Oxy,Aminotran_3,Methyltransf_2,Methyltransf_3,Methy
                     ltransf_7,PRISE,Cellulose_synt,Chalcone,ERG4_ERG24,FA_desat
                     urase,FA_desaturase_2,Methyltransf_11,polyprenyl_synt,SE,SQ
                     S_PSY,TPMT,UbiA,Lipoxygenase,Lyase_aromatic,HMGL-like,Chalc
                     one_3,Chalcone_2,Acetyltransf_1,UDPGT_2,GMC_oxred_N,GMC_oxr
                     ed_C,Amino_oxidase,DAHP_synth_1,DAHP_synth_2],[Dirigent]));
                     "
                     /cutoff=19290
                     /extension=3858
                     /product="lignan"
                     /clusterblast="2. NC_084820.1_c11	Rosa rugosa chromosome 1,
                     drRosRugo1.1, whole genome shotg... (75% of genes show
                     similarity)"
                     /clusterblast="3. NC_047656.1_c204	Prunus dulcis chromosome
                     7, ALMONDv2, whole genome shotgu... (75% of genes show
                     similarity)"
                     /clusterblast="4. NC_034015.1_c213	Prunus persica cultivar
                     Lovell chromosome G7, Prunus_pers... (75% of genes show
                     similarity)"
                     /clusterblast="5. NW_018921587.1_c84	Prunus avium cultivar
                     Satonishiki unplaced genomic scaf... (75% of genes show
                     similarity)"
                     /clusterblast="6. CAEKDK010000007.1_c178	Prunus armeniaca
                     isolate pruArmRojPasFocal genome a... (75% of genes show
                     similarity)"
                     /clusterblast="7. NC_065872.1_c10	Argentina anserina
                     chromosome 1, drPotAnse1.1, whole genom... (75% of genes
                     show similarity)"
                     /clusterblast="8. OZ184548.1_c213	Prunus brigantina genome
                     assembly, chromosome: 7 (75% of genes show similarity)"
                     /clusterblast="9. NC_091675.1_c307	Malus domestica
                     chromosome 15, GDT2T_hap1 (75% of genes show similarity)"
                     /clusterblast="10. CM018519.1_c295	Pyrus ussuriensis x
                     Pyrus communis cultivar Zhongai 1 iso... (75% of genes show
                     similarity)"
                     /clusterblast="11. NC_062274.1_c303	Malus sylvestris
                     chromosome 15, drMalSylv7.2, whole geno... (75% of genes
                     show similarity)"
     gene            3859..4218
                     /locus_tag="M0R45_003839"
     mRNA            3859..4218
                     /locus_tag="M0R45_003839"
                     /product="hypothetical protein"
     CDS             3859..4218
                     /locus_tag="M0R45_003839"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="KAK9948254.1"
                     /translation="MEEEKSVIGANQTLGGLGTFLRKCLFNVLSVGPIPHHIAFIMDGN
                     RRYAKRRNLPVGEGHKAGYLSLMSLLRYCFEMGVKYVTVYAFSIDNFKRKPDEVQTLME
                     LLQEKIEALLEKEVI"
                     /domain_record="plants/Prenyltransf (E-value: 6.3e-29,
                     bitscore: 100.2, seeds: 1408)"
                     /sec_met="Type: lignan"
                     /sec_met="Domains detected: Prenyltransf (E-value: 6.3e-29,
                     bitscore: 100.2, seeds: 1408)"
                     /sec_met="Kind: biosynthetic"
                     /sec_met="Percentage identity: M0R45_003840=50.0"
                     /kmer_dict="{'MEE': [0], 'EEE': [1], 'EEK': [2], 'EKS':
                     [3], 'KSV': [4], 'SVI': [5], 'VIG': [6], 'IGA': [7], 'GAN':
                     [8], 'ANQ': [9], 'NQT': [10], 'QTL': [11, 99], 'TLG': [12],
                     'LGG': [13], 'GGL': [14], 'GLG': [15], 'LGT': [16], 'GTF':
                     [17], 'TFL': [18], 'FLR': [19], 'LRK': [20], 'RKC': [21],
                     'KCL': [22], 'CLF': [23], 'LFN': [24], 'FNV': [25], 'NVL':
                     [26], 'VLS': [27], 'LSV': [28], 'SVG': [29], 'VGP': [30],
                     'GPI': [31], 'PIP': [32], 'IPH': [33], 'PHH': [34], 'HHI':
                     [35], 'HIA': [36], 'IAF': [37], 'AFI': [38], 'FIM': [39],
                     'IMD': [40], 'MDG': [41], 'DGN': [42], 'GNR': [43], 'NRR':
                     [44], 'RRY': [45], 'RYA': [46], 'YAK': [47], 'AKR': [48],
                     'KRR': [49], 'RRN': [50], 'RNL': [51], 'NLP': [52], 'LPV':
                     [53], 'PVG': [54], 'VGE': [55], 'GEG': [56], 'EGH': [57],
                     'GHK': [58], 'HKA': [59], 'KAG': [60], 'AGY': [61], 'GYL':
                     [62], 'YLS': [63], 'LSL': [64], 'SLM': [65], 'LMS': [66],
                     'MSL': [67], 'SLL': [68], 'LLR': [69], 'LRY': [70], 'RYC':
                     [71], 'YCF': [72], 'CFE': [73], 'FEM': [74], 'EMG': [75],
                     'MGV': [76], 'GVK': [77], 'VKY': [78], 'KYV': [79], 'YVT':
                     [80], 'VTV': [81], 'TVY': [82], 'VYA': [83], 'YAF': [84],
                     'AFS': [85], 'FSI': [86], 'SID': [87], 'IDN': [88], 'DNF':
                     [89], 'NFK': [90], 'FKR': [91], 'KRK': [92], 'RKP': [93],
                     'KPD': [94], 'PDE': [95], 'DEV': [96], 'EVQ': [97], 'VQT':
                     [98], 'TLM': [100], 'LME': [101], 'MEL': [102], 'ELL':
                     [103], 'LLQ': [104], 'LQE': [105], 'QEK': [106], 'EKI':
                     [107], 'KIE': [108], 'IEA': [109], 'EAL': [110], 'ALL':
                     [111], 'LLE': [112], 'LEK': [113], 'EKE': [114], 'KEV':
                     [115]}"
                     /ripp_evidence="{}"
                     /top_kmer_word="QTL"
                     /top_kmer_hits=11
                     /top_kmer_hits=99
                     /table="QTL"
                     /table="QTL"
     gene            4299..4928
                     /locus_tag="M0R45_003840"
     mRNA            join(4299..4436,4526..4719,4829..4928)
                     /locus_tag="M0R45_003840"
                     /product="hypothetical protein"
     CDS             join(4299..4436,4526..4719,4829..4928)
                     /locus_tag="M0R45_003840"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="KAK9948255.1"
                     /translation="MKATANNSNAVLLICVAYTSCDEIVHAVEESCKEKRKEIQAPNGG
                     KFDREAGLGTNTACNGNIERFEKGEKENAMVNHEVASNGLVEEVKESEKQHEKIPNVKL
                     VDVEKHICAVARFGFMEFGLGSSEFQRNHYYLEKKKKQV"
                     /domain_record="plants/Prenyltransf (E-value: 1.5e-07,
                     bitscore: 30.3, seeds: 1408)"
                     /sec_met="Type: lignan"
                     /sec_met="Domains detected: Prenyltransf (E-value: 1.5e-07,
                     bitscore: 30.3, seeds: 1408)"
                     /sec_met="Kind: biosynthetic"
                     /sec_met="Percentage identity: M0R45_003839=50.0"
                     /kmer_dict="{'MKA': [0], 'KAT': [1], 'ATA': [2], 'TAN':
                     [3], 'ANN': [4], 'NNS': [5], 'NSN': [6], 'SNA': [7], 'NAV':
                     [8], 'AVL': [9], 'VLL': [10], 'LLI': [11], 'LIC': [12],
                     'ICV': [13], 'CVA': [14], 'VAY': [15], 'AYT': [16], 'YTS':
                     [17], 'TSC': [18], 'SCD': [19], 'CDE': [20], 'DEI': [21],
                     'EIV': [22], 'IVH': [23], 'VHA': [24], 'HAV': [25], 'AVE':
                     [26], 'VEE': [27, 85], 'EES': [28], 'ESC': [29], 'SCK':
                     [30], 'CKE': [31], 'KEK': [32], 'EKR': [33], 'KRK': [34],
                     'RKE': [35], 'KEI': [36], 'EIQ': [37], 'IQA': [38], 'QAP':
                     [39], 'APN': [40], 'PNG': [41], 'NGG': [42], 'GGK': [43],
                     'GKF': [44], 'KFD': [45], 'FDR': [46], 'DRE': [47], 'REA':
                     [48], 'EAG': [49], 'AGL': [50], 'GLG': [51, 122], 'LGT':
                     [52], 'GTN': [53], 'TNT': [54], 'NTA': [55], 'TAC': [56],
                     'ACN': [57], 'CNG': [58], 'NGN': [59], 'GNI': [60], 'NIE':
                     [61], 'IER': [62], 'ERF': [63], 'RFE': [64], 'FEK': [65],
                     'EKG': [66], 'KGE': [67], 'GEK': [68], 'EKE': [69], 'KEN':
                     [70], 'ENA': [71], 'NAM': [72], 'AMV': [73], 'MVN': [74],
                     'VNH': [75], 'NHE': [76], 'HEV': [77], 'EVA': [78], 'VAS':
                     [79], 'ASN': [80], 'SNG': [81], 'NGL': [82], 'GLV': [83],
                     'LVE': [84], 'EEV': [86], 'EVK': [87], 'VKE': [88], 'KES':
                     [89], 'ESE': [90], 'SEK': [91], 'EKQ': [92], 'KQH': [93],
                     'QHE': [94], 'HEK': [95], 'EKI': [96], 'KIP': [97], 'IPN':
                     [98], 'PNV': [99], 'NVK': [100], 'VKL': [101], 'KLV':
                     [102], 'LVD': [103], 'VDV': [104], 'DVE': [105], 'VEK':
                     [106], 'EKH': [107], 'KHI': [108], 'HIC': [109], 'ICA':
                     [110], 'CAV': [111], 'AVA': [112], 'VAR': [113], 'ARF':
                     [114], 'RFG': [115], 'FGF': [116], 'GFM': [117], 'FME':
                     [118], 'MEF': [119], 'EFG': [120], 'FGL': [121], 'LGS':
                     [123], 'GSS': [124], 'SSE': [125], 'SEF': [126], 'EFQ':
                     [127], 'FQR': [128], 'QRN': [129], 'RNH': [130], 'NHY':
                     [131], 'HYY': [132], 'YYL': [133], 'YLE': [134], 'LEK':
                     [135], 'EKK': [136], 'KKK': [137, 138], 'KKQ': [139]}"
                     /ripp_evidence="{}"
                     /top_kmer_word="VEE"
                     /top_kmer_hits=27
                     /top_kmer_hits=85
                     /table="VEE"
                     /table="VEE"
     gene            5725..6274
                     /locus_tag="M0R45_003841"
     mRNA            join(5725..5785,5893..5984,6074..6274)
                     /locus_tag="M0R45_003841"
                     /product="hypothetical protein"
     CDS             join(5725..5785,5893..5984,6074..6274)
                     /locus_tag="M0R45_003841"
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="KAK9948256.1"
                     /translation="MALSVALHVLLSAFLLTKATAGTGVSQTTTPFGTLFVFQDPMTVT
                     ANRSSKQRRGSISIVGGTHNIKPADHPVVGGTGDFKLVQGYVTSSPVNLTGLTVTYKIA
                     FHLYWPPYATQAS"
                     /domain_record="plants/Dirigent (E-value: 2e-08, bitscore:
                     33.4, seeds: 297)"
                     /sec_met="Type: lignan"
                     /sec_met="Domains detected: Dirigent (E-value: 2e-08,
                     bitscore: 33.4, seeds: 297)"
                     /sec_met="Kind: biosynthetic"
                     /kmer_dict="{'MAL': [0], 'ALS': [1], 'LSV': [2], 'SVA':
                     [3], 'VAL': [4], 'ALH': [5], 'LHV': [6], 'HVL': [7], 'VLL':
                     [8], 'LLS': [9], 'LSA': [10], 'SAF': [11], 'AFL': [12],
                     'FLL': [13], 'LLT': [14], 'LTK': [15], 'TKA': [16], 'KAT':
                     [17], 'ATA': [18], 'TAG': [19], 'AGT': [20], 'GTG': [21,
                     75], 'TGV': [22], 'GVS': [23], 'VSQ': [24], 'SQT': [25],
                     'QTT': [26], 'TTT': [27], 'TTP': [28], 'TPF': [29], 'PFG':
                     [30], 'FGT': [31], 'GTL': [32], 'TLF': [33], 'LFV': [34],
                     'FVF': [35], 'VFQ': [36], 'FQD': [37], 'QDP': [38], 'DPM':
                     [39], 'PMT': [40], 'MTV': [41], 'TVT': [42, 97], 'VTA':
                     [43], 'TAN': [44], 'ANR': [45], 'NRS': [46], 'RSS': [47],
                     'SSK': [48], 'SKQ': [49], 'KQR': [50], 'QRR': [51], 'RRG':
                     [52], 'RGS': [53], 'GSI': [54], 'SIS': [55], 'ISI': [56],
                     'SIV': [57], 'IVG': [58], 'VGG': [59, 73], 'GGT': [60, 74],
                     'GTH': [61], 'THN': [62], 'HNI': [63], 'NIK': [64], 'IKP':
                     [65], 'KPA': [66], 'PAD': [67], 'ADH': [68], 'DHP': [69],
                     'HPV': [70], 'PVV': [71], 'VVG': [72], 'TGD': [76], 'GDF':
                     [77], 'DFK': [78], 'FKL': [79], 'KLV': [80], 'LVQ': [81],
                     'VQG': [82], 'QGY': [83], 'GYV': [84], 'YVT': [85], 'VTS':
                     [86], 'TSS': [87], 'SSP': [88], 'SPV': [89], 'PVN': [90],
                     'VNL': [91], 'NLT': [92], 'LTG': [93], 'TGL': [94], 'GLT':
                     [95], 'LTV': [96], 'VTY': [98], 'TYK': [99], 'YKI': [100],
                     'KIA': [101], 'IAF': [102], 'AFH': [103], 'FHL': [104],
                     'HLY': [105], 'LYW': [106], 'YWP': [107], 'WPP': [108],
                     'PPY': [109], 'PYA': [110], 'YAT': [111], 'ATQ': [112],
                     'TQA': [113]}"
                     /ripp_evidence="{}"
                     /top_kmer_word="GTG"
                     /top_kmer_hits=21
                     /top_kmer_hits=75
                     /table="GTG"
                     /table="GTG"
ORIGIN
        1 ggaatagtat cggacttcaa ttccaagttc caacccattt tcaattgaaa ccgccgattt
       61 tgtgttgagg acttgaggcc attcaacatg aggatcaaaa tgtttcattt ggcatctaaa
      121 tccaactcac tgaaggccaa atcattcttt tcaaacccca atgccagata gtggtgtgat
      181 tctaatgcca cattgttgct ctgctagtta tatacatttt ctcagtatta agctttcttt
      241 tgaagcaatg aagctaatag atatgtcttt cttgtcatat ttgataatgc aggcagaagt
      301 gaacttttta ggaaggcttt ctcatcccca accttgtcaa actattagga tactgttggg
      361 aagataagga gctactcctt gtttatgagt acatgcagag aggtagcttt ggagaatcat
      421 cttttcagaa gtacgtacaa aatcattgtg aaaataaaag ctttttgctt aagttcttca
      481 tcataaattt gtggtattga ctctataaat tcgctttgag cagggaatcc taacattgaa
      541 ccactatcgt gggacatcag aatcaaaata gctattggag cagcctcgag gcctggcatt
      601 tttgcacagt tcagaaaaac aaattatata tagagatttc aaggcctcga attattgctt
      661 gatggggttg tttttttttt ttttttttcc aatcccaacc tttccatctc ttattcagaa
      721 tattggattg tcctttgttc ctaacattta tgtatatatg cacatgtaca tcacattgac
      781 taagcctttg ttaattttcc tctccttgtc tgtatttatc ttcttacaga attacaatgc
      841 aaaaatcttc agattttgga ttggcaaaat taggaccact gctggcgaat cgcatgtgtt
      901 cgactagtat tatggggaca tatggttatg ctgctccaga atacatcgca acaggtaatg
      961 ataactatct gtggaagcta aagtttccaa aatttataca tgaagtacat gtttgttgtt
     1021 tgaatcggct ggtatatctg acttgtgcac tctaaattaa caggtcattt gtatgtgaag
     1081 agcgatgtgt atggcttcgg tgttgtgctg ctcgaaattt tgacagggtt acgagcacta
     1141 ggatacaaaa cgccctaagg aacaacttaa tctggttaga ctggatcaaa ccacttctcc
     1201 ctcataaaag aaagttgaaa accattatgg atgcaaggat ggaaggccaa tattccttaa
     1261 aggcagcaat acagacagca aacattactt taaaatgcct agccccggat ccgaaaagcc
     1321 gaccttccca tgaaagaagt cttggagaat tggaacagat tcaggcaatc agggaaaacc
     1381 caaagccatc ctttctaatt acctctagga acctacttct actcctcgat cctacgctct
     1441 tcaagagcct gttcgtcgtt cctcgcttcc cgccaggtat catgccactg aatgagataa
     1501 gcatctgcaa gaccaagtgc taagattaga ttcctacaaa ttaattgtat ttttcaacat
     1561 tgagattaga atgttcggac aatcgatcac ctttttgttc ttttcccctg ttgatttttt
     1621 cacatttttt gtagccattg ttttgattca taacaaattt ttgttcatgt agacaccagt
     1681 acttctgctg aatcagatga tcgataaatt gttgtataca ccacagtctc atctttacta
     1741 tgtcatttta cctcttttac atatcaatca catctcctgg atacttacct ttggaatacg
     1801 tagtaaacaa gcacataatc gctctttcct tttggggaat atctcaggcc gccgtgtaga
     1861 tttttgtgaa gacggtttta caaaaatttg tgacactttg acccctcgaa ctactcccaa
     1921 cttcgatcat gcacaaaaca gatcaacaat attgtacaga gtaaacactg tcttacatat
     1981 gtagtggtgt ttggttcttt taacttgagt caaactataa tttcagtttt ttagtttgga
     2041 ttattttccc tttggcctaa aagaaaattt ttgatcccaa gtcacaacaa aattaaggaa
     2101 tggatatgtg tcttgcacat ggataatatg tattttttat tatttgagaa tatatttttt
     2161 attctttgac aatagttttt attgttattt ggaagttttt ttttattttt tacagtagtt
     2221 ttttattatt tgacattagt tttattgtct atagtattag tttttcgtat tcagtggcat
     2281 ttttataaat aatgagaaaa aaatattgtg acatttttgt aaatattatg cggtgatatt
     2341 tttgtaaata ttaatgaatt tatgaagaat aaaaatattt ggtggttttt tgaagtttgg
     2401 tgaccttatg ggtaattttt taatgtaatt accatattcc cttctacatg ttgggcaaca
     2461 tgttaattaa ctaattacat atgtcaagtt ttggccaagt cactaattcg tccatcatcg
     2521 aaactttaaa aagaacaaga ggtattatat atagaaaata tgaaaccaca tagaccaaaa
     2581 tggaaacaat gcaaacttat atgaaaaaaa ctaaaatttt ccccaaattt tcatatgttt
     2641 tagggcataa atcaagccgt gaaatagcct cattgttaga aaccgtataa agaactaggg
     2701 gtattataaa ctatgatcac ataaccaaaa tgaaaaacaa tgccacataa actatatgaa
     2761 gaaaactcat aactgtactt tcccaaaaaa ttttattatg ttggaaagaa agccaaaacg
     2821 gcaaaacacc cataaaagcg cataacaaac attgtgaaat gcagggagtg cacctctcct
     2881 tttcggttat catcattcat cagtgctttt ataactttgt cctctctatg tatagggata
     2941 cgctttcggc tattcaattt cctgccaaac taaccagtca ctttcttcta aactcttctg
     3001 ggttcttcac ctttatctcc attttttgcg atcacagttt tttctttcat tttttaagtg
     3061 attatgcgtt tttaaaaaca actacatgtt tttgtggtag tagcagctcg ctaactgtta
     3121 tatataggcc tgaaacctgt tggttcttca ttgggttgcc agtgcttgac catcagttta
     3181 ttcaggtaag tcctttatgc attaacttct ttatctatga cttattcatt tagttctgct
     3241 agtgttgtgt gattatgatg cttcttcatg aacaactgta aataaagtat ggaactttga
     3301 atttctgggt atatatgttc atcatttgga atccgaaatt ggctgtaact actaagtaaa
     3361 gttgaatacc ttaattggta ttatttggat ttgatgaaag tatgcaatta agtacaagat
     3421 ttttagagta tatgttattg tgtatatatc tgtttttgct taagctagca ccaacttaaa
     3481 catcaaattc ccagaaaggg cctactttgt agtgttaatt atatggttaa tgcaaatttc
     3541 cttgataatc gaactaatca cgaagaaatt actgtaaagt tggacttgag gttctttccg
     3601 aattattgtg ctggtgtatc tcctctagta tttgacgaaa tgcttcattt agtatagttt
     3661 tcttgtgtgt ggactttctt tgtacctatg tcctttattt ggttttggac ctatactcag
     3721 tattttggat cccttggctt tattgtatag tttgtatgga ctatggaggg tgtcaagctt
     3781 acatgcagac tgaaattttg ttcctcttgg gcagggtcgt tttggcttta gtcgttagct
     3841 tctgttgtag atcctacaat ggaggaggaa aaaagtgtta ttggtgcaaa ccagactttg
     3901 gggggtttgg gtactttttt gaggaaatgc ttgtttaatg ttttgtctgt tggcccgatt
     3961 cctcatcaca tcgcgttcat catggatggg aaccgaaggt atgcaaagag gcggaactta
     4021 ccggttgggg aaggccacaa agccggatac ttgtctctca tgtccctgct taggtactgc
     4081 ttcgaaatgg gagtgaagta tgtcaccgtc tatgccttca gcattgacaa ttttaagaga
     4141 aaaccagacg aggtgcaaac tctaatggag ctattgcagg agaagattga agcactgctt
     4201 gagaaagaag ttatctaaac caatatggtg tcagagtata ctttattggt aacttgaaac
     4261 ttctgagtga gcctgtcagg attgctgctg aaaatgcaat gaaggcgact gccaacaact
     4321 ccaatgctgt gcttttaatc tgtgtggcct atacttcatg tgatgagatc gtccacgctg
     4381 tagaagaatc ctgtaaggag aaaaggaaag aaattcaagc acctaatgga ggcaaggtta
     4441 gcaatggtgt gattcatgga gttggagagg gagagatggt taatggtgtg actgagactg
     4501 aagttcacaa atcctgcaac aatagtttga tagagaagca ggattgggta ctaatacagc
     4561 ttgcaatggt aatattgaaa ggtttgaaaa gggggaaaag gaaaatgcaa tggttaatca
     4621 tgaagttgca agcaatggtc ttgttgaaga ggttaaagag agtgagaagc agcatgagaa
     4681 aattcctaat gtaaagctgg ttgatgttga gaagcacatg tacatggcag tggcacctga
     4741 tcccgacatt ctaatccgaa ctgctggtga gacccggctg agcaatttcc ttctttggca
     4801 atctagtaac tgcccattgt actcccagct gcgctgtggc cagatttggg tttatggaat
     4861 ttggtttggg cagttctgaa ttccagcgta accattacta tttggagaag aaaaagaagc
     4921 aggtgtaaca ttctcaatgc cactcagaga tcatgtggta ctcctgcata gatttacagg
     4981 atcatgattg aaattccggg atgagagtca atgtacttac cctaaactgt atgacctaat
     5041 atatatgcta tgtattatgt agtttttgtt gtttatctat atacatgaat acaaatatct
     5101 tagttcctgt tgctatttac aagttttaat gtctgtgact tcaataccaa tttggttatt
     5161 caagtctaga accatataat caacttcagc agctgagata taatccttgt tctcactgct
     5221 ctattcagag aacaagacag aaggactcga tcgagtaaga tggactggat aaaggtgatc
     5281 gtagtttaaa gttcatggtg actatagctt tttgaaaatg aagtaccaac aatatcaact
     5341 tttcttttat aaagtctcct gcatgaactt caaagctagc agagaaataa atgaccacat
     5401 attcagataa cctaacacct ctttggatgg ccacgatcaa aaccacgatg acgaggtaaa
     5461 accctttcct attgagacaa aagtcaattc acaatgttgg tttaatcgaa atggacaagc
     5521 aaaggaaaat agatcgatcc actgaggaag aaatttaagt ggttgaaatt taagagaaat
     5581 ttaggtggtt gaaatttcat cgtctcacaa tcatgatttc cttctaacaa ctcgacaaaa
     5641 aactcatcca ccaacagcca actgcgactt atagtataaa gagtactaca cctgaactat
     5701 gctaaattgc tacatcacat tattatggct ctctctgtag ctcttcatgt tctactttct
     5761 gcattcctct taacgaaagc caccggtacc tctcacctcc accaccacca caaccaactc
     5821 aagtcccttc acttcgccct ctttcaacac aaaccataaa caaaactgga tacatcgtgg
     5881 tgaatggtgt agccggaaca ggcgttagtc aaactacaac gccttttggc accctgtttg
     5941 ttttccagga tccgatgact gttacagcca acagatcttc aaaagtggct gggatagctc
     6001 aaggaacttc cataacttcc agcttggacg ggcttgagag catttcattg ctaagataac
     6061 cttgcgtttg aagcaacgcc gtggttcgat ttccattgtt gggggcacac ataatattaa
     6121 gccggctgat catcctgttg tgggaggcac aggtgatttc aagcttgtgc agggctatgt
     6181 gacatcgtct ccagtcaatc tcacaggctt aactgttacg tacaagattg cattccacct
     6241 ttactggcct ccatatgcaa ctcaagcttc ttaatcccag agggttcgat aagtatgaac
     6301 ccctctaagt gtgtttgtat ctccactttt gctgtataat ctttaatcta agatttgaat
     6361 atgaaaatct atggtgattg attagatcat cgattagatt atttagatct aaagaccaaa
     6421 cccaaaaaga aggatagaac aatagtcaat ctcttaacat ttcttcaatc aattggtttc
     6481 ataagtagat acagaaattt caagttacaa cgtacaaacc acgtccacgg ttataatacc
     6541 actcgaaaag cttgaacaag gtgcaagcat ttacaggata aaaagtgatg gtaagattag
     6601 atggggtatt acctttcacg tctacctgat caagaattca acactacgcg atactactaa
     6661 tcaaagaatc aaatactatg aagcaagcag ggaaagcttc acaggatatt gcattggcca
     6721 ccgaattctg aacccagaat caagaccgag gcttgtgcag acgaggtcta ttgcaaaaaa
     6781 tccgcccatt ggccctcaca aatgcagcta tagccacact tagaccccca cataaatgaa
     6841 aagaacaagt gccgtagatc gtacctaact gcaaaattag tgaagacaag catcatttac
     6901 ttgcaagatt tgcagagatg cctacaatgc agtattgttt ctgtccagaa atgaacccac
     6961 tatgaactaa tattacccca gtcccttcct accctttcac caccaaagag atgattttct
     7021 ccaaagctaa cttggtcaca acatgtactg tttttactta ccttgcctca atgacaaagt
     7081 cgcaaaaaag aacccagtca aaacaatgac aaagccagtg ggaatgactg caaaatgaaa
     7141 taatgtgatt aagagactga taaaggctga gagtagggta ataaaaacaa atttgagttt
     7201 gctcttatcc aaagaagaaa tcattcacat gcaatgttat tgtagtaggc tcaatagtga
     7261 aatttatgaa aagttatatt ggaaatcatt cagagaagtc ctaaaatcac aaaattaatg
     7321 gacatctttt ttttttgcca aaaattaatg gacatctagg ttttactcac agcaacagcc
     7381 tcaagtcctc ccttttgaga tgatggtgtc atatctttgc tgacggagac aatgtaatgt
     7441 ccttgcagaa ggtcaattgc atccttcagg atttccacca aaagatgaaa ttgtcagcag
     7501 ataaagttgc agatatttct tcacattcac atctcacata tgatgggcag tgaaggaaag
     7561 aaatggcagt gaaaaatttc acatgaaaag aaagaaaaaa gaaagagaga gatgacatca
     7621 aaggaagcag acctacctgt ttagttccat cacagaagtt attgtaataa tagcgtagaa
     7681 gggaattgat tccatcctta acgattcctt gcattgtccg ctggccacat ctaagatcca
     7741 gccaaataga acaaacttaa tactaagaag acaaggaatt aggtttccca tcttattctt
     7801 aagtcaatgc tataatcctt gtgccaacat acatatatgc tgcatgtgaa agataaacaa
     7861 gttcccaatg caaattagat ccatggaagt gtaccttaca aaatcccttt caaagcagga
     7921 gtgccagaat attgaatgct tacatcatcc ccatgatcag cccacactgg taaacagaaa
     7981 gaattagaag taatacatgc acatccgccg acatggggca ctcaactgta aatctctata
     8041 tgctaaattt taaattttaa agcagagagg ggggggggga gaagagagat gggactcaca
     8101 aattttaaag cattcatcta aattggggtg tgagctaata gtttcttcag cagcaaaaat
     8161 gccaagcctc ctagttggca ttccaacata tttcggccta tcatactctg ccagccatga
     8221 tactttcagg gaacaaatga tgcagaaaaa gatataaagg catatgacaa caatcaacag
     8281 taatgtgaaa aaaaaaaaaa gtagtttggc ttaggctgca taactaatat ggttatttag
     8341 tgatcaaatt attttccgaa ctctcataat gacaaacatt attgaaatct ttggataatt
     8401 gttcttacct gggtaacatt tgtacgatct aagcaatcaa tgcaattggt ccttacaact
     8461 cctaattgct ccttcatttt ctcacccttt tcattcaata gaagatacct acatttcaat
     8521 catagaaaat gagcaaaaga agaggcaaga ttacatccca tattgttagt cattgagtat
     8581 aattgagtta cgacaaatac atctcttcac acatatgcat gggagtagaa aataacaaaa
     8641 tgtgtgtgtc taaatatcaa aagaaaaagg agttttagtt tatttcatcg accatcactt
     8701 tcaaaaataa ttccagaatg ttttcctagt aactctgaac tttgttggtt ttacaattta
     8761 atccaatagg tacggggttc aaaatcgctt cccaattcct cagttactat ttaagggcag
     8821 gatgggatgc acagtgtaca catatgatca tgacttcatt tgcaagagca agaagaggag
     8881 gttgttaact taatatacat tgttggttga ttccctaaca gcctaagctt ttggttctgg
     8941 agtatggtgg tagtccaaca ctggtaatta taatgatttt tcacatattc gcatctatgt
     9001 taaattcaca taaatatgaa atattaaaca tagcagaaaa actggtgtct gggactactc
     9061 tatttatgct gaactaaccc tcaaaagtaa aatgactttt gaagcaacaa ataataatga
     9121 agcaataaat aatttagtac atttattgag ttagatattg attaccagat gacgaaaaca
     9181 tacccatttc tgtcgagaaa atctactatt tgttcataaa ggatagagag gcgctcaaaa
     9241 tggatgtgtc cacagatatg atgaaaatcg aagtgccagt atctacaata ttcagtaggt
     9301 atcaccatga aacagatcta ttttgaatgc caaataaaga aaaaggctta aaaaggatta
     9361 gatgaaagta aattctacct tagatcatca ctaacaatat gctgcattgc atttgcaaat
     9421 ttttcactca agcgtccttc acctccatgc tggtaagata ataaactatc aggagaaata
     9481 atactcaaaa ctgtatgctt atatatgatc tatatatatg tatatacata cacacaaata
     9541 tgatctatat atacacacac atacacacac atatgtgtgt gtgtgcctct gcgtggatat
     9601 tgcacgagtg tgcgtatata tcgtttatta tcagatattc cacaaaattt ggcaaagaaa
     9661 gtgcgcaccg tgttaacaag atcaacagct aacactgccc cgtacttttt cttaaatcca
     9721 gaaaatgccg ctctgccact cgcggctgca taatgtgcag tgaacgagaa gtcaaatgga
     9781 gataaaatac tacagctcaa gaacaataga taagagaaga agtaatggtc aactcacagc
     9841 ttcctcaagt cgcacaattt caaacttagg cttatatgtt agatcaacaa tttgatccca
     9901 aagcaatgga attgaccccc taacctgcaa taaacaatta ctggagctga aaacatgaag
     9961 gattacatat aagtgtaaag cacaaactta tgtggaagaa agcatctttg atcagaaaaa
    10021 aatcaaaaaa tttgcaaaca tgcacttgta agtctggtta aagatcctgg cagtccttta
    10081 tcttggcagt cttgaaacac ttttgttaat tttaaccatt aaatgagtaa at
//
